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Bookmarks and beyond: epigenetics in tumorigenesis and teaching outside the textbook

Aurora Taira
University of Helsinki

Abstract: The human body consists of a wide variety of cell types that carry an identical DNA sequence in their nuclei. Epigenetic regulation, or ‘bookmarking’ of the genome, enables flexible gene regulation and the establishment of distinct cell identities. In this talk, we will explore the role of DNA methylation in tumorigenesis and challenge the traditional view of cancer as a genetic disease. Lamarck’s giraffes will guide us toward the concept of epigenetic memory, while a pulla-baking team will help illustrate Unix piping and how to teach bioinformatics clearly.

Bio: Aurora Taira is an interdisciplinary teacher and researcher working at the interface of medical genetics and computational biology. In her research, she has characterized the role and regulation of DNA methylation in tumorigenesis, with particular contributions to studies on colorectal cancer and uterine leiomyomas. Her work has been published in high-impact journals, and she applies bioinformatics and data-driven approaches in her research. Alongside her research, she has nearly a decade of experience teaching bioinformatics at the University of Helsinki, with responsibilities ranging from hands-on exercises to the design and implementation of new courses.